Description:
Pomalidomide is a third-generation immunomodulator. Several clinical trials have shown that pomalidomide-containing combination regimens have a good effect in the treatment of relapsed and refractory multiple myeloma and can improve the prognosis of patients. In 2013, the US Food and Drug Administration (FDA) approved pomalidomide for the treatment of relapsed and refractory multiple myeloma, and in May 2020 for the treatment of AIDS-related Kaposi's sarcoma. Pomalidomide was approved for marketing in my country in November 2020. Considering that most clinicians in my country currently have little experience with the use of pomalidomide, the members of the consensus expert group referred to relevant research progress and clinical practice at home and abroad to form a Chinese expert consensus on the clinical use of pomalidomide, with the with the aim of providing Chinese clinicians with drug use.
Product description:
Brand name: Pomalid 4mg
Active ingredient: Pomalidomide 4mg
Package: 21 capsules
Manufacturer: Natco Pharma LTD.
Shipping - worldwide
Pomalidomide has shown good efficacy and safety in newly treated, relapsed and refractory MM, especially in MM patients with first relapse and post-relapse maintenance treatment. NCCN guidelines also recommend it for the treatment of relapsed and refractory PCNSL and MF-related anemia. It also shows therapeutic potential in patients with AML and MDS and is well tolerated and safe. With the introduction of pomalidomide in my country, the experience of clinicians in the use of medicine will continue to increase, and the disease areas that can be explored will expand, which means more useful references for the clinical use of pomalidomide. This consensus represents only the expert panel's guidance on the use of pomalidomide and serves as a reference for clinicians. In practical applications, it is also necessary to develop appropriate, individualized treatment plans based on the clinical characteristics of different patients. Not exactly pocket-friendly when talking about the cost of Pomalidomide .
Dosage
Repeat the 28-day course with 4 mg orally daily from days 1-21. days until disease progression. Please read [Dexamethasone Dosage].
Warnings and precautions
o Hematological toxicity: Neutropenia is the most frequently reported 3/4. grade side effect. Monitor patients for hematologic toxicity, especially neutropenia.
o Hepatic: liver failure, including death; liver function tests should be checked monthly.
o Allergic reactions: Angioedema and severe dermatological reactions have been reported. Discontinue POMALYST for angioedema and severe dermatologic reactions.
o Tumor lysis syndrome (TLS): Monitor patients at risk for TLS (ie, those with high tumor burden) and take appropriate preventive measures.
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